Xxx inglic com

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With the muscle-type nicotinic acetylcholine receptor (n ACh R), appropriate transmembrane helix-helix associations are also required to mask an endoplasmic reticulum retention motif and thus to signal that the mature receptor is ready to traffic to the cell surface.

In the absence of effective helix-helix associations, the immature form remains in the endoplasmic reticulum and is targeted for degradation.

1) influence function, we mutated each residue to Ala, and characterized how each mutation influenced agonist-induced channel gating using two-electrode voltage clamp electrophysiology.

Xxx inglic com-34

Xxx inglic com-35

2), although numerous GLIC mutants and one ELIC mutant did not express and/or function.The other archetype, exemplified by ELIC and both the nicotinic acetylcholine and serotonin receptors, has relatively few aromatic contacts that are detrimental to function.These archetypes likely have evolved different mechanisms to balance the need for strong M4 “binding” to M1/M3 to promote folding/expression, and the need for weaker interactions that allow for greater conformational flexibility..Structural and sequence comparisons suggest that our functional data may reflect the existence of distinct archetypes for the TMDs of p LGICs.One archetype, exemplified by GLIC, the glycine (Gly R), the GABA receptor and the glutamate activated chloride channel (Glu Cl).

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